Laura Buckton
NSW Health Pathology, Department of Chemical Pathology, Prince of Wales Hospital, Randwick, NSW.

A 37-year-old female presented at 24 weeks gestation with recent onset of acne and hirsutism. Biochemical investigations revealed hyperandrogenism with elevated testosterone (14.9 nmol/L, non-pregnant reference interval: <2 nmol/L) and androstenedione (40.6 nmol/L, non-pregnant reference interval: 0.9 – 7.5 nmol/L), which continued to increase in the second half of her pregnancy. This was her first pregnancy after a history of infertility, and she had been diagnosed with gestational diabetes mellitus. At 39⁺⁴ weeks gestation she delivered a healthy baby girl via caesarean section. Postpartum follow up showed normalisation of her androgen levels, an improvement in her hirsutism, however her acne persisted. This case presentation will discuss the causes, pathogenesis and challenges associated with diagnosing androgen excess during pregnancy.